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Moreover, it can also decrease the size of kidney stones ( via its anti-oxidative, anti-inflammatory and anti-fibrotic properties ( via Nrf2 in various kidney diseases models ( via the upregulation and activation of Nrf2 ( 3.2.1.5 Hesperetin Hesperetin, a natural bioactive phytochemical from citrus plants, exhibits wide pharmacological therapeutic effects on cancer, cardiovascular diseases and diabetes ( via increasing Nrf2 and p-Nrf2 levels in kidney tissue ( via Nrf2-ARE signaling pathway ( 3.2.1.6 Astragaloside IV A

Moreover, KD is not suitable for all diseases and even the ratio difference in the KD formula may lead to unexpected therapeutic outcomes, thus increasing the need for precision nutrition and nutrigenomics research

doi:10.1093/qjmed/90.3.213

There was also a negative relationship between the total sulphate and glucuronide conjugates and the other metabolites, indicating that if the estrogens are not biotransformed, they are converted into sulphate or glucuronide conjugates, which agrees with the current understanding of estrogen biotransformation

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