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For instance, the cysteine protease legumain can cleave TrkB, potentially generating soluble receptors that act as BDNF scavengers, thereby attenuating signalinga mechanism that may be relevant in neurodegeneration (Holzner et al., 2023)

30 , 335350.e4 (2020)

Bioavailability of dietary doses of 3H-labelled tea antioxidants (+)-catechin and (-)-epicatechin in rat

In addition, NGR1 inhibited the increase of LDH, AST, and CK-MB in the serum of diabetic mice

Second, the execution core of ferroptosis involves the peroxidation of polyunsaturated fatty acid-containing phospholipids(PUFA-PLs) in membrane lipids, leading to the massive accumulation of cytotoxic lipid peroxidation derivatives such as specific lipid hydroperoxides and reactive aldehydes like 4-hydroxynonenal(4-HNE), ultimately causing irreversible damage to plasma membrane integrity (Guo et al., 2024)

Oxidant stress and skeletal muscle glucose transport: roles of insulin signaling and p38 MAPK