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doi: 10.1196/annals.1395.041

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The directionality of this relationship is debated: low testosterone may cause metabolic dysfunction, metabolic dysfunction may suppress testosterone, or both may be downstream of common upstream causes

Adjustment for treatment effects For the study of PD patients receiving dopaminergic treatments, it is important to note that using 3-O-Methyldopa (3-OMD, 3-methoxytyrosine) as a covariate to adjust for treatment effects has limitations

L-carnitine is unlikely to produce meaningful results in isolation any potential benefit observed in research was alongside dietary and lifestyle changes, so supplements should be viewed as an adjunct to, not a replacement for, a balanced diet and regular physical activity

Int J Mol Sci (2019) 21(1):300