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Moreover, a number of molecular, cellular, pharmacological, and metabolomics studies indicate that mitochondrial metabolic activity is required for generating sufficient levels of ROS to trigger ferroptosis [47, 62]

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Am J Respir Crit Care Med 184(12):13901394 Lee JS, Collard HR, Anstrom KJ, Martinez FJ, Noth I, Roberts RS, Yow E, Raghu G, Investigators I (2013) Anti-acid treatment and disease progression in idiopathic pulmonary fibrosis: an analysis of data from three randomised controlled trials