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In the literature, a statistically significant decrease in OPG activity was observed in rats with periodontitis compared with control groups [38, 56, 57]

Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24 S -hydroxycholesterol from the brain into the circulation

Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)

In parallel, glutamate metabolism is disrupted, and excess glutamate contributes to motor neuron degeneration through excitotoxicity, calcium overload, and modulation of astrocytic reactivity 14

doi: 10.1016/j.sleep.2018.05.034 75