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Large Cap Core Plus Fund Class R6 JPMorgan US Large Cap Cap Core Plus Fund R2 John Hancock Fundamental Large Cap Core Fund Class I JPMorgan Large Cap Value Fund R6 JPMorgan Large Cap Value R5 JPMorgan Large Cap Value Fund R2 John Hancock Managed Account Shares Investment Grade Corporate Bond Portfolio John Hancock Managed Account Shares Non-Investment Grade Corporate Bond Portfolio John Hancock Managed Account Shares Securitized Debt Portfolio JPMorgan Municipal Money Market Fund Agency Shares John Hancock Funds II Short Duration Credit Opportunities Fund Class A John Hancock Funds II Short Duration Credit Opportunities Fund Class C John Hancock Funds II Short Duration Credit Opportunities Fund Class I JPMorgan SmartRetirement Blend 2045 Fd R5 JPMorgan Mortgage Backed Securities Fund R6 JPMorgan Mid Cap Equity Fund Cl C JP Morgan Mid Cap Equity Fund- R2 Jacob Micro Cap Growth Fund Investor Class Shares James Micro Cap Fund Janus Henderson Mid Cap Value Fund - T Shares John Hancock Money Market Fund Class C JP Morgan Mid Cap Equity Fund- R5 John Hancock Funds II Multimanager 2060 Lifetime Portfolio Class I JPMorgan Municipal Money Market Fund E Trade JPMorgan Market Expansion Enhanced Index Fund R2 JPMorgan Mid Cap Growth Fund R5 JPMorgan Managed Income Fund L Class JPMorgan Managed Income Fund - I JPMorgan Mid Cap Growth Fund R6 JPMorgan Mid Cap Growth Fund-R3 JPMorgan Mid Cap Growth Fund-R4 Janus Henderson Enterprise Fund - I Shares JPMorgan Mid Cap Growth Fund R2 Janus Henderson International Managed Volatility Fund - A Shares Janus Henderson International Managed Volatility Fund - C Shares JPMorgan Emerging Markets Equity Fund Class L Jacob Micro Cap Growth Fund Institutional Class Shares Janus Henderson International Managed Volatility Fund - I Shares Janus Henderson International Managed Volatility Fund - S Shares Janus Henderson Mid Cap Value Fund - L Shares John Hancock Fds II Emerging Markets Debt Fd Class A John Hancock Funds II Emerging Markets Debt Fund Class C John Hancock Fds II Emerging Markets Debt Fd Class I Money Market Portfolio JPMorgan Research Market Neutral Fund Cl A JPMorgan Research Market Neutral Fund Cl C JPMorgan Research Market Neutral Fund I Class Janus Henderson Global Allocation Fund - Moderate - A Shares Janus Henderson Global Allocation Fund - Moderate - C Shares Janus Henderson Global Allocation Fund - Moderate - I Shares Janus Henderson Global Allocation Fund - Moderate - S Shares Janus Henderson International Managed Volatility Fund - N Shares Janus Henderson Global Allocation Fund - Conservative - D Shares JPMorgan Income Fund - R6 JPMorgan Income Fund I Class JPMorgan SmartRetirement Blend 2045 Fund I Class JPMorgan Total Return Fund A JPMorgan Total Return Fund C JPMorgan Total Return Fund R6 Janus Henderson Multi-Sector Income Fund - N Shares JPMorgan Total Return Fund R5 JPMorgan Total Return Fund I Class JPMorgan Total Return Fund R2 Janus Henderson Multi-Sector Income Fund - A Shares Janus Henderson Multi-Sector Income Fund - C Shares Janus Henderson Multi-Sector Income Fund - D Shares JPMorgan U.S

The conservative protocol takes longest (thirteen weeks) but uses moderate doses throughout that are easier to measure

Cagrilintide-Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes (REDEFINE 2)

doi: 10.1186/s40360-016-0088-3