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Unlike its cousin GHK-Cu, which occurs naturally in human plasma, AHK-Cu is entirely synthetic

It could be speculated that the altered methylation status of this gene, as opposed to Gnrh or Kiss1 , might be subtle enough for the reproductive system both to sense and tolerate without implementing compensatory mechanisms to overcome it, allowing SRD5A1 to function in this context

These are uncommon at standard therapeutic doses and typically indicate the dose needs adjustment

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doi: 10.1016/s0196-9781(03)00040-8