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A healthy individual can reach peak plasma concentrations of EGCG in 12 h after a single oral dosage in the morning after an overnight fast

doi: 10.1038/s41586-019-1170-y 189 JiangZLimSOYanMHsuJLYaoJWeiYet al

[DOI] [PubMed] [Google Scholar] Storkey C

Acetylcholine is responsible for mood regulation, psychomotor activity, and sleep (438), by activation of central muscarinic receptors, rather than nicotinic receptors (153)

Although preclinical studies and limited clinical trials provide supportive evidence, larger and well-designed human clinical trials are still required to confirm long-term efficacy, dose-response relationships, and safety in metabolic disease conditions

Structure 7 , 877889 (1999)