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It was reported that CYP11A1-derived vitamin D3- and lumisterol-hydroxy derivatives protected primary human keratinocytes against radiation and UVB-induced damage, which is associated with Nrf2-regulated antioxidants responses ( 3 and 20,23(OH) 2 D 3 play as antagonists of ROR and ROR to inhibit the activity of IL17 promoter (Supplementary Figure S4 and Supplementary Table 2)

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