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Carvalho FerrazLPereiraPFerreiraJV

Ann Thorac Surg 111(1):296-300, 2021

When autophagy is impaired, increased p62 competes with the DLG motif for binding to the Keap1 DC pocket and inhibits the ubiquitination of Nrf2, causing Nrf2 stabilization and the increased expression of cytoprotective genes

To allow for localized protrusions, Rac1 activity is regulated by RCC2 48,49,51,52

The same dose must produce the same plasma concentration in the same species under the same conditions

Macrophage migration inhibitory factor (MIF), a pleiotropic cytokine/chemokine that signals through interactions with the CD74 receptor and its auxiliary receptors CXCR2, CXCR4, and CXCR7 [168, 169], is elevated in ALD patients [170] and in mice chronically exposed to ethanol [171]