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microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling

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It is likely that the repression of Can1 internalization in nitrogen-starved yeast cells is a cargo-specific response rather than reflecting a general repression of endocytosis upon nutrient deprivation, since other studies propose that starvation rather favors endocytosis, conceivably to enhance protein degradation and, thereby, increase nutrient availability to maintain cell function