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Around 500 million years ago, coinciding with the colonization of terrestrial environments and the advent of a more complex nervous system during the CambrianDevonian periods, microglia and oligodendrocyte lineages are thought to have emerged (Freeman and Rowitch, 2013)

Gong et al., 2021

Despite NACs relevant therapeutic potential, in several experimental studies, its effectiveness in clinical trials, addressing different pathological conditions, is still limited

Front Bio sci 2004

Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates mitochondrial dysfunction via pi3k/akt/enos signaling pathway in diabetic tubulopathy

ROS can initiate different modes of cell death through their oxidative effects on specific redox-sensitive proteins