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This rhythm originates from the suprachiasmatic nucleus (SCN), where light exposure transmits neural impulses to the SCN via the retinohypothalamic tract, synchronizing the activity of the SCN and the nocturnal secretion rhythm of melatonin with the 24-h light/dark cycle

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For first-line drugs, isoniazid (INH) resistance is primarily associated with mutations in the katG gene, which encodes the catalase-peroxidase enzyme responsible for activating INH (Rivire et al., 2020)

Sirtuin 3 as a regulator of oxidative stress Sirtuin 3 is an NAD + -dependent deacetylase that plays a role in mitochondrial metabolic processes, including energy production, oxidative stress, the tricarboxylic acid cycle, and other processes (Bause et al

However, many of its visible and internal signs are linked to a decline in cellular function and hormone production