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The advent of induced pluripotent stem cell (iPSC) technology has revolutionized the study of NDDs by enabling researchers to model disease-specific neuronal phenotypes using patient-derived cells 2635

Similar findings were also observed when using pharmacological inhibitors of autophagy (KU55933 and Verteporfin) whereas, the use of Tat-beclin1, an autophagy enhancer , remarkably increased the number of myelin segments by more than two-fold when compared to vehicle controls or KU55933/Verteporfin treated OLs (Bankston et al., Signaling Events Regulating OL Metabolism Netrin-1 Signaling Promotes Mitochondria Elongation and Glycolysis Understanding how both intrinsic and extrinsic signaling events can affect oligodendroglial metabolism will be key to the development of therapeutic agents to either enhance metabolic control of oligodendroglial functions or counter metabolic dysregulation

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As well, the synthetic retinoid (ST1926) had a greater effect on MDA-MB-231 and MCF7 cell lines represented by binding to -catenin and cyclin D1, which regulates the Wnt/catenin signaling pathway (75)

Estradiol, Obesity and Hypogonadism. Physiological Research , vol

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