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Sibutramine has only little clinical relevance as an antidepressant but enhances weight loss due to an increase in energy expenditure and inhibition of food intake (37)

De Clercq, I

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Preferably, the bulge may be located in the sense strand

Not only did they uncover nearly 20 antiviral compounds that potently suppressed HSV infection with minimal host-cell toxicity, but they also found striking cell type-specific differences in the potency of novel and existing HSV antivirals