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Additionally, excessive ROS leads to oxidative damage to DNA and proteins, as well as lipid peroxidation of cell membranes, ultimately resulting in cell death (21)

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274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)

This may represent an important rate-limiting step during maturation that could benefit from enhanced Gsta4-activity

Id say the effect lasted about 24 hours

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