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However, these studies either used super-physiological GH doses ( Previous studies have revealed that GH controls the generation of IGF-1 by targeting the gene transcription of IGF-1 via STAT5 in diverse physiological situations ( Crosstalk Between Circadian Clock System and GH/IGF-1 Axis Regulatory Effect of the GH/IGF-1 Axis on the Circadian Clock System There are very few reports to identify the regulatory effect of the GH/IGF-1 axis on the circadian clock system

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The treatment reduced triglycerides, non-esterified fatty acids, and ferritin levels