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Growth hormone and IGF-1 can influence neurotransmitter systems involved in sleep regulation, including GABA-ergic pathways that promote sleep initiation and maintenance, and adenosine systems that regulate sleep pressure and depth

These biochemicals initiate and amplify inflammatory signaling throughout the body 16

Coronal hippocampal slices were prepared with a vibrating tissue slicer and maintained at room temperature in a solution of oxygenated artificial cerebrospinal fluid (ACSF)

10.1111/jcmm.13975 80 LiuC.YalavarthiS.TambralliA.ZengL.RysengaC

Furthermore, ketamine has been shown to reduce other neuropathy related inflammatory markers as well

de Wouw MVan, Walsh AM, Crispie F, van Leuven L, Lyte JM, Boehme M, Clarke G, Dinan TG, Cotter PD, Cryan JF (2020) Distinct actions of the fermented beverage kefir on host behavior, immunity and microbiome gut-brain modules in the mouse