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The secondary endpoint was to determine safety during a 12-month post-operative period, while secondary outcomes were the same safety and efficacy measures as above, but at 12 months

K3, which has potent growth inhibitory effects via oxidative stress in many kinds of cancer cell lines, was used in the majority of these experimental investigations (60, 65)

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Berberine also induces apoptosis via the mitochondrial pathway, promoting the release of cytochrome c from mitochondria, activating caspase-8, 9, and subsequent caspase-3 cascades, and triggering apoptosis by inhibiting the expression of Bcl-2 while increasing pro-apoptotic proteins (85)

van der Hel et al

Taking a lot of other supplements