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This leads to the inability to absorb B12 and thus deficiency

Consistent with previous studies in mice, we also observed an increase in branched-chain amino acids (Leucine, Isoleucine, and Valine) in the brains of both DL and CR-fed female mice 12,83

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Mechanism of cytotoxicity of anticancer platinum drugs: evidence that cis-diamminedichloroplatinum(II) and cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) differ only in the kinetics of their interaction with DNA

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And previous studies in our laboratory have shown that conversion of Cys residues into Sec residues in GPx1 and GPx4 could result in dramatic loss of the catalytic activity 15,16