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Methylglyoxal, the dark side of Glycolysis

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Conte B, George B, Dasari A, Overman MJ, Estrella J, Jiang Z, Machado K, Mello CL, Ferrarotto R, Hoff PM, Yao JC, Rashid A, Kopetz S

Except for weight gain and cushingoid facies (which were more frequent with prednisolone), other adverse effects were not different in the two groups

Furthermore, ACSL4-dependent ferroptosis mechanism is associated with metabolic lipid reprogramming, and T cell infiltration, indicating the crosstalk between immune system and lipid metabolism (Liao et al., 2022)