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The bone graft substitute was also implanted into beagles mandibular defects for 4 and 8 weeks, and the dogs were euthanized under excessive pentobarbital anesthesia and sampled for micro-CT scanning (Fig

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50 The microbiota plays a crucial role in various biological functions of the host, including the development of the immune system, protection from harmful microorganisms, food breakdown during digestion, and production of micronutrients and bioactive compounds

Metabolic diseases are becoming increasingly common in modern society, such as diabetes, NAFLD, and non-alcoholic steatohepatitis (NASH) due to people's lifestyles and irregular circadian rhythms [96]