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Synthesis of purines from serine/glycine can also be tracked by 13 C 6 -glucose tracing as 13 C 6 -glucose-derived carbon is incorporated into ATP through the production of ribose (M + 5) and through serine contribution to the purine ring via 10-formyl-THF (M + 1 or M + 2) and glycine (M + 2)

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Its important to note that the recommended daily intake of vitamin B12 varies depending on age, gender, and pregnancy status

Then things like toxic exposure, mold toxicity, liver-kidney disease, and infections are probably less common causes

Kanaoka Y, Boyce JA (2014): Cysteinyl leukotrienes and their receptors