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Older adults are also more likely to take medications that can interfere with B12 absorption, Manson says

What the Human Data Show Long-term human data for Epithalon are limited compared with small-molecule drugs, but several cohort studies, some with more than twelve years of follow-up, have reported measurable improvements in melatonin rhythm, circadian function, glucose tolerance, and reductions in all-cause mortality among older patients

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The evidence base is almost entirely preclinical: rodent models consistently show accelerated tissue repair, gut healing, and neurological protection, but human RCT data remains largely absent