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At low concentrations, ROS modulate many cellular processes through redox-dependent signaling including proliferation, differentiation, apoptosis, immune regulation, cellular adaptation [1113] and now it is becoming clear that they also participate in the (negative) regulation of steroidogenesis [7, 8, 10, 23, 55, 56]

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2.16 Antioxidant activities and lipid peroxidation of liver and kidney tissues Kits made for laboratory purposes were purchased from Biodiagnostic, Diagnostic, and Research Reagents in Cairo, Egypt, to determine the antioxidant enzyme activity of glutathione peroxidase (GHPx) and superoxide dismutase (SOD) concentrations in both liver and kidney tissues (catalog numbers GP 25 24 and SD 25 21, respectively)