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Molecular Pharmaceutics 2021, 18: 3418-3428

Das A, Belagodu A, Reiter RJ, Ray SK, Banik NL

A., Hussein, R

Additionally, the activity of multiple microRNAs (miRNAs), such as miR-18a, miR-155, or miR-429, can inhibit hypoxia-inducible HIF-1, while others like miR-145 suppress, and miR-558 enhance, the expression of hypoxia-inducible factor HIF-2 through direct interactions with EPAS1 (endothelial PAS domain-containing protein 1) mRNA, the transcript of the gene encoding HIF-2 [60]