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Within the GBM microenvironment, elevated CSF-1 signaling promotes the recruitment and polarization of macrophages toward an immunosuppressive, protumorigenic M2 phenotype, increasing tumor growth, invasion, and immune evasion 314 (Fig

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Among these, the , -unsaturated aldehyde 4-hydroxy-2-nonenal (4-HNE) and di-aldehyde malondialdehyde (MDA) are most studied (Fig

S, N, O, G and E symbolize the thiolate, amino, carboxylate, glycinyl- and glutamyl carboxylate (the latter two pertaining to glutathion residues) sites, respectively