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Excess copper stabilized HIF-1, the rate-limiting component of HIF-1, causing its accumulation in the cytoplasm, which activated HIF-75, regulated vascular endothelial growth factor(VEGF)expression, and promoted tumor angiogenesis (148)

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Similarly, Rao et al (50) found that increased intracellular iron disrupts the neuromelanin-iron complex in neurons, releasing free iron ions that damage neurons and lead to neuromelanin leakage

Neuroinflammation, oxidative stress and the pathogenesis of Parkinsons disease

Doehring, E., Feldmeier, H