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While the cause of ME/CFS is unknown, many factors are through to contribute to the development of the illness, such as: (1) bacterial or viral infections, or (2) physical or emotional trauma, including from an accident, concussion, immobilization, surgery, trauma, or even a significant emotional stress such as loss of a loved one

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Release of cytochrome c from heart mitochondria is induced by high Ca 2+ and peroxynitrite and is responsible for Ca(2+)-induced inhibition of substrate oxidation

10.1159/000335859 67 Georgiou-SiafisS

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