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Serum UA levels also decreased with worse sleep quality in PD patients, suggesting its significance as a biomarker of sleep disturbance in PD patients (Zhou et al., 2023)

Modern Western diets are often deficient in n-3 fatty acids and disproportionately high in n-6 fatty acids such as arachidonic acid, contributing to a pro-inflammatory state ( 1.3.4 Transitional metal ions Dysregulation of essential trace metals particularly iron (Fe), copper (Cu), and zinc (Zn) is increasingly recognized in AD pathophysiology

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Low molecular weight complexes contained IGF-I or IGF-II bound to an insulin regulated liver derived protein IGFBP-1 (17, 18), at first called the 28 kDa binding protein or PP12 (19)