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However, grape juices ability to increase the production of NO in endothelial cells does not appear to rely solely on its major antioxidant named resveratrol

The oxidative stress-induced weakening of the fibrous cap covering the plaque, due to the degradation of extracellular matrix components by matrix metalloproteinases (MMPs), is a key factor in plaque instability [75]

In comparison to monocyte-derived macrophages from healthy volunteers, macrophages from patients with active CD were more susceptible to ferroptosis induced by in vitro exposure to H 2 O 2

They also display microgliosis, astrocytosis and synapse loss, in addition to cognitive impairment at 6 months of age

Furthermore, whether Exos regulate other molecules implicated in GSH synthesis or iron metabolism to affect ferroptosis remains an open question

It is one of the most powerful anti-oxidant that is naturally occurring in our bodies