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Resolution of ROS-induced G-quadruplexes and R-loops at transcriptionally active sites is dependent on BLM helicase

Figure 7 These data also raised the possibility that the ADA assay was not detecting true ADA, but 1:1 complexes of endogenous anti-TNF antibodies and trimeric TNF, since partially bound TNF trimer could still theoretically bridge two molecules of AMG 966 in the antibody assay, and the etanercept spiked into the assay buffer to address this issue would not be able to neutralize partially bound TNF

Read Less It is also involved in the metabolism of every cell in the body, particularly affecting DNA synthesis and regulation

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