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Osteoporosis Isn't a Calcium Deficiency (Doctors Get This Wrong) Can calcium make osteoporosis worse

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Interestingly, two thirds of such replacements are in highly and moderately conserved (50% to 99%) amino acids, and relatively few are in fully conserved amino acids (where they might be lethal) or in poorly conserved amino acids, where presumably they simply would not cause G6PD deficiency

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Pharmacological Basis of Therapeutics