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1 Introduction Rheumatoid arthritis (RA) is a multifactorial autoimmune disease of unknown etiology mainly characterized by synovial hyperplasia, pannus formation, as well as cartilage and bone destruction, resulting in joint pain, stiffness, and swelling

Rondanelli M, Solerte SB, Fioravanti M, Scevola D, Locatelli M, Minoli L, Ferrari E

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They further clarify that the extract contained various important phytochemicals that had anticonvulsive effects by suppressing the pro-inflammatory cytokines TNF-, IL-1, IL-6, and IFN- and increasing the levels of anti-inflammatory cytokines TGF- and IL-10 in the hippocampal tissue of the animal model

We began our validation by performing 72 hr dose-response assays against APR-246 in the presence or absence of doxycycline (Fig

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