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Well these animals, if you look at them after the age of four months, I mean the mice look like, I mean they're accelerated aging, they're wrinkled, they have no hair

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Proton pump coupled to cytochrome c oxidase in mitochondria

For example, cultured astrocytes subjected to oxygen and glucose deprivation showed a decrease in mitochondrial membrane potential, possibly caused by the mitochondrial permeability transition pore (mtPTP) opening, which leads to a loss of intramitochondrial contents, mitochondrial respiration and ATP production [48]