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5.2 Safety and toxicological concerns Even as nanoencapsulation solves bioavailability issues, it introduces new questions about the safety of ingesting nanoparticles over time

doi: 10.1160/TH07-01-0039 15 JeonC

In addition, ADCs can also exert an extracellular action on neighbouring cells via the release of the payload after intracellular cleavage of the linker (bystander effect), which is mediated by the proteases localised in lysosomes

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Mortazavi, M

I am just relaying that the most common refrain on various forums is that it has no discernable effect