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doi: 10.1073/pnas.1921828118 133

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ALP mutations Subnormal ALP levels have been reported in patients with hypophosphatasia (HPP), a rare inherited systemic metabolic disease caused by mutations of the tissue-nonspecific ALP ( TNSALP ) gene

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A delicate balance of protein synthesis, trafficking, and degradation requires the interplay of complex cellular factors to achieve proteostasis [212]

Physiological levels of ROS can act as second messengers to regulate physiological activities such as intracellular homeostasis and signal transduction, while excess ROS exerts cytotoxicity and induce apoptosis in tissue cells ( Figure 4 ) (56)