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In a mouse model of Sjgrens syndrome, pharmacological inhibition of Cyp51a1 with ketoconazole suppressed CD4 T cell activation and proliferation, reduced T cell infiltration in salivary gland lesions, and alleviated disease symptoms [33]

It regulates GPX4-mediated GSH synthesis by interacting with CREB, suppressing GPX4 transcription, and enhancing ferroptosis sensitivity

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