This imbalance of the gut microbiota and continued exposure of the colonic epithelial cells to urea is harmful to intestinal epithelial barrier function as it aids the disruption of the mucus layer and lowers the expression of tight junction proteins (Vaziri et al., 2013
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Their potential therapeutic relevance in disease-specific contexts is discussed based on preclinical and observational data and should be regarded as hypothesis-generating rather than evidence of clinical efficacy
coli , characterized by diminished energy metabolism, inhibition of cell membrane and wall synthesis, and a weakened stress response and antioxidant capacity
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