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(2016) Gao et al

Maini MK, Peppa D

doi: 10.1111/MPP.12211/SUPPINFO 45 LiangX.RollinsJ

Both Type A and Type B deficiencies result in the loss of sulfite oxidase activity, also observed in isolated sulfite oxidase deficiency and characterized by severe neurologic abnormalities in affected patients

In contrast to citral, medium- to long-chained -apocarotenoids exhibit a conjugated double bond system with delocalized electron density which reduces the polarization of the ,-unsaturated double bond by electron-withdrawing properties of the aldehyde/ketone which is key to glutathionylation

In RA, this pathway is aberrantly activated, particularly in synovial tissue cells such as synovial fibroblasts