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Together, these data suggest that in most CRPC subtypes, AR directly binds and represses the BCL-2 locus in a ligand-dependent manner and inhibition of AR signaling would block AR occupancy at key regulatory regions such as ARBS1 allowing for transcriptional activation of BCL-2

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Many protocols suggest the following structure: Monday through Friday : Daily TB-500 injections Saturday and Sunday : Rest days Duration : 4-12 week cycles followed by rest periods Some treatment plans specify injections every 3.5 days rather than daily administration .[1] This less frequent approach can be particularly beneficial for those who prefer fewer injections while maintaining therapeutic benefits