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One possible answer is that increased intracellular concentrations of either cation can lead to cellular hyperexcitability

Br J Dermatol 164:11881200 Cooper GM, Hausman RE (2009) The cell: a molecular approach, 5th edn

Viruses were used to infect Vero E6 cells (ATCC CRL-1586) grown in Dulbeccos Modified Eagles Medium (DMEM) (Gibco) supplemented with 1% penicillin/streptomycin (Sigma) and 2% fetal bovine serum (Sigma)

In some markets, authorities scrutinise products marketed for skin lightening more closely

The vast majority of evidence comes from MCT or hypoxia animal models, whose pathological characteristics differ from human PH, lacking in-depth verification in models that are more similar to human disease states

Based on these studies and studies involving GSH depletion, it was concluded that a reduction in GSH levels and GPX activity before infection could decrease spread of the virus due to apoptosis caused by oxidative microenvironment (48,49)