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As GDF-15, these effects are reduced with the blockade of activin A receptor in animal models (54)

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The in vivo stimulation of cyclin-dependent kinase activity by homocysteine was confirmed in humans with severe hyperhomocysteinemia

NRF2 depletion exacerbates IMQ-induced psoriasis-like symptoms and negates the therapeutic effect of SFN To further investigate the mechanism of SFN, we utilized both wild-type and NRF2-deficient mice for modeling and treatment