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1 By limiting melanin creation, you may see improvements in hyperpigmentation and a more even complexion

et al., 2025), while certain TCM formulations containing licorice may precipitate pseudohyperaldosteronism, exacerbating hypertension and fluid retention in volume-sensitive CKD patients (Sabbadin et al., 2024)

Research confirms that Pycnogenol enhances endothelial NO production by increasing endothelial nitric oxide synthase (eNOS) activity and protects the generated NO from degradation by scavenging superoxide anion radicals, thereby improving its bioavailability (250)

Pharmaceutics 14 , 404 (2022)

Key terms used in the search were AMPK, natural product, and diabetes, which were further combined with type 2 diabetes, hyperglycemia, cardiovascular disease, nephropathy, neuropathy, complications, mechanism, phenolic metabolites, terpenoids, Terpenoids, Quinones, and alkaloids. The final search was completed in September 2024, and the searches were limited to literature published in English

Wang Y Lung Microbiota Participated in Fibrous Microplastics (MPs) Aggravating OVA-Induced Asthma Disease in Mice