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Total spot UV and total skin tone showed continuous improvement in the placebo group until Week 8, but this trend declined at Week 12

The accumulation of itaconate causes a metabolic break by inhibiting the enzymic activity of succinate dehydrogenase

[DOI] [PubMed] [Google Scholar] 15.Winterbourn C.C

Compared to the large volume of literature regarding the impact of ROS on muscle fatigue, evidence that NO production directly contributes to the development of muscle fatigue is sparse

In melanocytes 4-HNE, through adduct formation, alters protein function, contributing to oxidative stress-induced cellular dysfunction, which mainly concerns on the functioning of cellular antioxidant system, acceleration of protein degradation, inhibition of melanocyte proliferation, photoaging processes, but also disruption of the intercellular interactions between melanocytes and keratinocytes 101,102,103

Tao Z-H, Han J-X, Xu J, Zhao E, Wang M, Wang Z, et al