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AR directly binds to the BCL-2 genomic locus to repress its transcription We subsequently conducted molecular studies to demonstrate that AR directly represses BCL-2 transcription and ARPI relieves this inhibition leading to BCL-2 upregulation (Fig

(2020) align with our observations

RT-PCR was performed using C57BL/6J wild type P1 mouse cochlea cDNA and PCR products were Sanger sequenced

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In affected tissues, multiple microbial populations invade the submucosa, accompanied by impaired neutrophil recruitment