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Dopamine plays a crucial role in modulating the reward network in chronic insomnia disorder (CID), particularly in the context of comorbid depression, where genetic variations related to DA can differentially affect functional connectivity within the nucleus accumbens and broader reward networks

Dihexa is not FDA-approved for any indication in the United States

Recent clinical trials have either been limited or did not report significant therapeutic benefits [51]

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Diasio RB (2001) Current status of oral chemotherapy for colorectal cancer