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Mechanistically, lactate stabilizes HIF-1, repressing pro-inflammatory microglial markers such as a cluster of differentiation (CD)-86, inducible nitric oxide synthase (iNOS), IL-6, and NF- while enhancing anti-inflammatory mediators such as arginase-1, CD206, Chitinase 3-like 3 (Chi3l3, a marker for anti-inflammatory M2 microglia/macrophages), transforming growth factor (TGF)-, and IL-10 via NF-B suppression [182] (Fig

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GR is a flavoprotein belonging to the family of NADPH-dependent oxidoreductases

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In accordance with expectations, no signal was detected with AptaCtrl and Apta7

H., Wong, G., Gane, E., Kao, J.-H