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Chronic low-grade H 2 O 2 biases hypertrophic signalling and fibrosis via redox-sensitive kinases and TGF- crosstalk (Liu and Desai 2015)

Additionally, PQ downregulates SLC7A11 and GPX4 expression and upregulates cyclooxygenase-2 expression, thereby promoting oxidative stress and ferroptotic cell death ( 4.2 Genetic models 4.2.1 SNCA models Overexpression of wild-type or mutant (A53T, A30P) -syn induces Lewy body-like inclusions in dopaminergic neurons, leading to significant neuron damage and degeneration