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It is well documented that distinct types of cells within the TME, including TAMs, TANs, TILs, MDSCs, CAFs, and ECs, modulate metabolic and immunologic responses

In addition to damaging the airway, alveoli and pulmonary vessels, COPD also damages the circulatory system, nervous system, motor system and other systems, resulting in remarkable extrapulmonary adverse effects (Vanfleteren et al., 2016)